They showed that NP induced cell proliferation and progesterone receptor gene expression in MCF-7 cells, and activated cell proliferation in ovariectomized rat endometrium [1]. (2016). Read more, Bis(2-methoxyethyl) phthalate was included in Annex XIV of REACH on 14th June 2017. ?jW(.#|>M]A{/j
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. Fabio Bacci, Pablo Campo, in Reference Module in Earth Systems and Environmental Sciences, 2021. The substance entered Annex XIV of REACH for its endocrine disrupting properties.
phenol branched nonyl In in vitro and in vivo testicular cancer cell proliferation assay, the nanomolar range of a realistic mixture of 4-tertiary-OP (4-tert-OP) and 4-NP, which corresponds to environmental doses, promoted a maximum proliferation increase of seminoma-derived (TCam-2) and embryonal carcinoma (NT2/D1) cell lines, via CREB-phosphorylation through a rapid, ER36-PI3 kinase nongenomic pathway [75]. }: vs5<
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u.{M'WRh^o')t:~yU9vU+6(41KH&)SENObm2\X3SVd3` %PDF-1.4 Occurrence of nonylphenol in wastewater effluent from activated sludge plants (035gL1), as well as river water (3.0gL1) and groundwater (2.0gL1) has been documented for four decades (Commission of the European Communities, 1981). APs can bind to ER and induce vitellogenin gene expression in animals due to their estrogenic activity [82]. Several studies previously reported that estrogen/ERs signaling can regulate TGF-/Smad signaling in the following manner. Sumpter and Jobling suggested that NP contained in effluent from sewage treatment works is associated with vitellogenesis in male rainbow trout [5].
branched nonylphenol ethoxylated cas molecular structure The miniaturized and automated sample preparation techniques, as exemplified by magnetic solid-phase extraction (SPE) and liquid phase microextraction (SPME) have become the promising technologies for analysis of organic residues (Fig. NP has estrogenic activity by binding to estrogen receptors (ERs) in both in vitro and in vivo assay systems. Kim, in Encyclopedia of Toxicology (Third Edition), 2014. What must you know before starting such application? Lower Explosive Limit (LEL): data unavailable, Upper Explosive Limit (UEL): data unavailable, Autoignition Temperature: data unavailable, Vapor Density (Relative to Air): data unavailable, Ionization Energy/Potential: data unavailable. In another in vivo experiment of mammary tumorigenesis, fetal exposure to 4-normal-OP (4-n-OP) enhanced the induction of mammary tumors induced by DMBA in rats [93]. Since 1975, Dr. Ehrenstorfer has led the way in producing pesticide reference standards. Prolonged contact with skin causes irritation. +{{cartData.totalItems - displayNumberOfProducts}} additional products, Enzyme activators, inhibitors & substrates, Standards for environmental regulatory methods, Process materials, geological, cement & soils, COVID-19 research and reference materials. After receiving your order confirmation, please contact us using the 'Contact us' form. According to the data provided by U.S. Environmental Protection Agency NP and nonylphenol ethoxylates (NPEs) Action Plan ([RIN 2070-ZA09], /18/2010), general population exposure to NP has been confirmed by biomonitoring data from breast milk [77], umbilical cord blood [78], and urine [79]. How are cosmetic color additives regulated in the U.S.? OP-treatment, however, delayed and inhibited gland-formation and suppressed ER expression in the invaginated-luminal and glandular epithelium at this time. Effect of TCS and OP on breast cancer growth in xenograft mice. Your punchout session will expire in1 min59 sec. EcoMundo is a specialist in chemical substances, their action on human health and the environment as well as the international regulations that govern chemical risk (REACH Regulation, CLP, Cosmetics and OTCs, Biocides, Food, etc.). Chemicals/Toxicology Whether the substance works with a threshold or not is not determined for these endocrine disruptors. <> Figure 7.5. Nonylphenol (NP; CAS: 25154-52-3, 84852-15-3, 104-40-5, 136-83-4, 11066-49-2) is a synthetic organic chemical produced in large volumes worldwide. Nonylphenol (NP) and octylphenol (OP) are kinds of APs, which are a family of organic compounds obtained by the alkylation of phenols, and are widespread in household products, cleansers, cosmetics, and insecticides, leading to a global environmental and human contamination [75]. BG-1 cells were seeded in 6-well plates and treated with E2 (109M), OP (106M), or NP (106M). ;U[.Q6RmumP* e=A_RUIY-2;GeV7nUk].eIV^}V``
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?UQ!6Ne7t(t0S'skvi+oBF1~H]UVUZwP^^F=>O : {{entry.product.biosafetyLevel == -1 ? The immunohistochemical investigation did not reveal any abnormalities in expression of the proto-oncogene c-fos, mitotic inhibitor p21, or EGF antigen, although the apoptotic index in the luminal epithelium was slightly increased in the OP-treated group. Something went wrong, please try again later. for 1+3, enter 4. (USCG, 1999). The watch list, to be formalized by 12 January 2022, will indicate guidance values for nonylphenol. Read more, Coal tar pitch was included in Annex XIV of REACH on 14th June 2017. Our products are produced to the highest quality, with all analytical measurements performed under our ISO/IEC 17025 scope of accreditation and a leading product range manufactured according to our ISO 17034 accreditation. ScienceDirect is a registered trademark of Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V. A low molecular-weight polymer. We sit down with two of our expert scientists - Savvas Xystouris, AXIO PT, and Dr Ehrenstorfers Dan Biggerstaff - where we talk about how analytical science is fighting back against the effects of pollutants. The impacts of NP in the environment include feminization of aquatic organisms, decrease in male fertility, and the survival of juveniles at concentrations as low as 8.2g/L [81]. PND 14, the second week of life, is coincident with the normal time for differentiation when the luminal epithelium invaginates into the stroma to form uterine glands. We generate it for you in 5 minutes! endobj LGC will process your personal data in accordance with all applicable data protection rules and regulations. 1.4 [85]. Furthermore, because of continuous discharge to wastewater, the substance is subject to pseudo-persistence effects.
disulfide nonylphenol oligomer molecular structure Contact with eyes causes irritation.
However, if you would like to, you can change your cookie settings at anytime. National Ocean Service, Bisphenol A (BPA), a primary monomer in polycarbonate plastic and epoxy resins, and nonylphenol (NP), a degradation product of the non-ionic surfactant alkylphenol polyethoxylates, occur in products to which humans are widely exposed. When administered with a diet mixed with 10, 100, or 1000ppm of 4-n-OP throughout the pregnancy period and given 10mg DMBA by gastric intubation 50 days after birth, fetal exposure to 100 and 1000ppm 4-n-OP enhanced the early incidence and number of mammary carcinomas while it did not enhance the incidence and number of benign proliferative lesions, implying the mammary cancer risk imposed by the fetal exposure of 4-n-OP during pregnancy. Its considered also an indirect additive used in food contact substances. 5n.w/8qegfhFV(4=pgjVSs*7|qwz_cr1faFB wg/l;}onGgCedI;h/oy\smic$N
bRH7T In stock. 313% indicates that this is a member of the EPCRA section 313 Nonylphenol Ethoxylates category.
chemicals Current approaches in sample preparation for trace analysis of selected endocrine-disrupting compounds: Focus on polychlorinated biphenyls, alkylphenols, and parabens. Taisen Iguchi, Kunihiko Yamazaki, in Neuroendocrine Regulation of Animal Vocalization, 2021.
degreaser In MCF-7 breast cancer cells, TGF--mediated transcriptional activity was inhibited by estrogen [86]. SLg
According Li, Jin, and Snyder (2018), the analysis of nonylphenols (NPs) and their precursors NP ethoxylates (NPEOs) (Fig. Javascript is currently disabled in your browser. ]]]U|cF!OW}~0P##[[m7@6nt@7&wz<5F}|||&`FP3%#AEvOo1pTe n^M?Hr(rbH}Td+J$cW=DUd8XkvJ_1rZ 4-nonylphenol is an estrogenic endocrine active chemical that is a derivative from ethoxylated alkylphenol, a non-ionic surfactant present in pesticide formulation as adjuvant and is known to contaminate food and drinking water. Please add to your cart and checkout as normal. (A) After tumor formation in the mammary fat pads of the mice was observed, the ovaries of each mouse were removed by ovariectomy (OVX). Yolk-sac Atlantic salmon fry exposed to waterborne E2 (2g/L) or NP (10g/L) for 21 days and raised for one year in clean freshwater experienced higher mortality than unexposed fish during grow-out in freshwater (Lerner et al., 2007). Software development, Headquarters: 195 Rue Jean-Jacques Rousseau, 92130 Issy-les-Moulineaux, Office: 34 Avenue des Champs-lyses, 75008 Paris, Subsidiary: EcoMundo, 503, 10th floor, Teheran-ro, Gangnam-gu, Seoul, South-Korea, Subsidiary: 4284 Rue de la Roche, Montreal, QC H2J 3H9, Subsidiary : 160 City Road, London, EC1V 2NX, Subsidiary: c/ Pallars, 193 Barcelona 08005, Subsidiary: Unit No. For environmental concentrations of NP, the values cover a wider range. The animals were then treated with corn oil, E2, OP, or TCS delivered via subcutaneous injection three times per week and were monitored weekly for 8 weeks. The occurrence of NP in the environment is mostly the result of metabolic degradation of NPEs and related alkylphenol ethoxylates (APEs). We use the most advanced analytical techniques to characterise our reference materials, so that you can rely on the scientific integrity of the data contained in your Certificate of Analysis. Track the controlled substances in your products and identify the non-conformances. Triton or 4-Nonylphenol, branched and linear, ethoxylated, 4-Nonylphenol, branched and linear, ethoxylated [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof], Intrinsic property for which it was included in Annex XIV of REACH, Latest date to submit the authorisation dossier to ECHA. There is no information on whether NP is carcinogenic in laboratory animals or in humans. v\?6ucXL}@OB The other three chemicals are currently under data analysis, and risk assessment of these chemicals will be conducted in the near future.
NP and OP bind to ER and induce ER-dependent gene transcription through ERE promoter in yeast and mammalian cells [83]. By continuing you agree to the use of cookies.
ether glycol polyethylene cas lookchem basic ER suppressed Smad3-dependent transcription by binding to Smad3, and estrogen inhibited TGF- signaling by promoting Smad2/3 ubiquitination and subsequent degradation [88,89]. Please enable it to use this website. Therefore, they are sometimes being detected in relatively higher concentrations in human and environmental samples. Votre adresse email ne sera pas publie. Chemicals having anti-thyroid hormone activity have also been reported, using amphibian metamorphosis assay [5,6]. including trade names and synonyms. Mp>2GII&UA{ jK,VdDeM,>0(}ShbMSiRvJ*BG^1LT:2C'I p|orM3"z;zUEEa6'}E3 E:(pD'd7ya)SLX5!fdVL>mFQC$*jA1)ZnNLJ*H#ZHZM+Ht ICzENlSt:nSX:9SF|/N"=y^-AR ]8v%|qC8)a;. Subscribe to receive our monthly newsletter! In addition to fetal exposure to 4-n-OP, neonatal exposure to 4-tert-OP also caused abnormal expression of ER and subsequent alteration of cell proliferating activity in the developing Donryu rat uterus [94]. This study suggested that 4-tert-OP and 4-NP have the potential to enhance cancer progression in estrogen-responsive organs including ovary by manifesting an estrogenic effect in inhibiting TGF- signaling. 4-tert-OP was also revealed to accelerate MCF-7 breast cancer growth in cellular and xenografted mouse model by regulating cell cycle-related genes through an ER-mediated pathway [92]. ALPHA(NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXYPOLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXYPOLYOXYETHYLENE, ETHANOL, 2-[2-[2-[2-(4-NONYLPHENOXY)ETHOXY]ETHOXY]ETHOXY]-, GLYCOLS, POLYETHYLENE, MONO(NONYLPHENYL) ETHER, 3,6,9,12,15,18,21-HEPTAOXATRICOSAN-1-OL, 23-(NONYLPHENOXY)-, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSAN-1-OL, 29-(NONYLPHENOXY)-, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 26-(NONYLPHENOXY)-, OMEGA-HYDROXY-ALPHA-(NONYLPHENYL)POLY(OXY-1,2-ETHANEDIYL), POLY(OXY-1,2-ETHANEDIYL), ALPHA-(2-NONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(4-NONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(4-NONYLPHENYL)-OMEGA-HYDROXY-, BRANCHED, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(ISONONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXY-, POLY(OXY-1,2-ETHANEDIYL), ALPHA-(NONYLPHENYL)-OMEGA-HYDROXY-, BRANCHED, POLY(OXY-1,2-ETHANEDIYL),ALPHA-(NONYLPHENYL)-OMEGA-HYDROXY, POLYETHYLENE GLYCOL 450 NONYL PHENYL ETHER, POLYETHYLENE GLYCOL MONO(NONYLPHENOL) ETHER, POLYETHYLENE GLYCOL MONO(NONYLPHENYL) ETHER, POLYETHYLENE GLYCOL NONYLPHENYL MONOETHER, POLYETHYLENE GLYCOLS MONO(NONYLPHENYL)ETHER, POLYETHYLENEOXIDE MONO(NONYLPHENYL) ETHER. Please note, shipping and tax are calculated on the checkout page. There is some evidence that NP affects the immune system in laboratory animals and limited evidence that it affects thyroid function.
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